Drug interactions
Capecitabine + Goserelin
Severity: Minor
Capecitabine and Goserelin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine has rarely been linked to QT prolongation and cardiac toxicity, and androgen deprivation with goserelin may also lengthen the QT interval. The combined effect is theoretical and usually small.
What this interaction means in plain words
Capecitabine and Goserelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Capecitabine belongs to Oncology; Goserelin belongs to Endocrine.
Why it happens
Possible additive QT prolongation, though capecitabine's QT effect is not well established.
What to do
Consider an ECG in patients with existing cardiac disease or other QT-prolonging drugs, and keep potassium and magnesium normal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Goserelin
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Goserelin?
MediHelp rates the interaction as minor. Capecitabine and Goserelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Capecitabine has rarely been linked to QT prolongation and cardiac toxicity, and androgen deprivation with goserelin may also lengthen the QT interval. The combined effect is theoretical and usually small.
How serious is the interaction between Capecitabine and Goserelin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG in patients with existing cardiac disease or other QT-prolonging drugs, and keep potassium and magnesium normal.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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