Drug interactions
Capecitabine + Lacosamide
Severity: Minor
Capecitabine and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lacosamide is only partly cleared by CYP2C9, with CYP2C19 and CYP3A4 also involved. Capecitabine is not a clinically established CYP2C9 inhibitor, so a meaningful rise in lacosamide is unlikely.
What this interaction means in plain words
Capecitabine and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Capecitabine belongs to Oncology; Lacosamide belongs to Central Nervous System.
Why it happens
Theoretical weak CYP2C9 inhibition; not clinically established.
What to do
No dose change is needed. Monitor for dizziness, ataxia and PR interval effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Lacosamide?
MediHelp rates the interaction as minor. Capecitabine and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lacosamide is only partly cleared by CYP2C9, with CYP2C19 and CYP3A4 also involved. Capecitabine is not a clinically established CYP2C9 inhibitor, so a meaningful rise in lacosamide is unlikely.
How serious is the interaction between Capecitabine and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for dizziness, ataxia and PR interval effects as usual.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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