Drug interactions
Capecitabine + Tiotropium-olodaterol
Severity: Moderate
Capecitabine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT interval prolongation, and beta2 agonists can add to arrhythmia risk through hypokalemia and increased heart rate. The risk is modest at inhaled doses but matters in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Capecitabine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and beta2-mediated sympathetic stimulation.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium abnormalities. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capecitabine and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Capecitabine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT interval prolongation, and beta2 agonists can add to arrhythmia risk through hypokalemia and increased heart rate. The risk is modest at inhaled doses but matters in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Capecitabine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium abnormalities. Monitor for palpitations or syncope.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
