Drug interactions
Capivasertib + Crizotinib
Severity: Moderate
Capivasertib and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may raise capivasertib levels, increasing risk of hyperglycemia, diarrhea, rash and other toxicities.
What this interaction means in plain words
Capivasertib and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4-mediated metabolism of capivasertib.
What to do
Reduce the capivasertib dose per labeling when given with a moderate CYP3A inhibitor. Monitor blood glucose and for rash and diarrhea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Crizotinib?
MediHelp rates the interaction as moderate. Capivasertib and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib may raise capivasertib levels, increasing risk of hyperglycemia, diarrhea, rash and other toxicities.
How serious is the interaction between Capivasertib and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the capivasertib dose per labeling when given with a moderate CYP3A inhibitor. Monitor blood glucose and for rash and diarrhea.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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