Drug interactions
Capivasertib + Entacapone
Severity: Minor
Capivasertib and Entacapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is metabolized by CYP3A4, and inhibitors can raise its exposure and the risk of hyperglycemia, diarrhea and rash. Entacapone is not a recognized clinically significant CYP3A4 inhibitor, so the effect is theoretical.
What this interaction means in plain words
Capivasertib and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Capivasertib belongs to Oncology; Entacapone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by entacapone, not established as clinically relevant.
What to do
No empirical dose change is needed for capivasertib. Monitor blood glucose and tolerability as per routine capivasertib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Entacapone?
MediHelp rates the interaction as minor. Capivasertib and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Capivasertib is metabolized by CYP3A4, and inhibitors can raise its exposure and the risk of hyperglycemia, diarrhea and rash. Entacapone is not a recognized clinically significant CYP3A4 inhibitor, so the effect is theoretical.
How serious is the interaction between Capivasertib and Entacapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed for capivasertib. Monitor blood glucose and tolerability as per routine capivasertib care.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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