Drug interactions
Capivasertib + Eslicarbazepine
Severity: Moderate
Capivasertib and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is a CYP3A4 substrate, and inducers reduce its exposure, possibly lowering antitumor efficacy. Eslicarbazepine is a weaker inducer, so the effect is likely smaller.
What this interaction means in plain words
Capivasertib and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine induces CYP3A4, increasing capivasertib clearance.
What to do
Consider a non-inducing anticonvulsant and monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Eslicarbazepine?
MediHelp rates the interaction as moderate. Capivasertib and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capivasertib is a CYP3A4 substrate, and inducers reduce its exposure, possibly lowering antitumor efficacy. Eslicarbazepine is a weaker inducer, so the effect is likely smaller.
How serious is the interaction between Capivasertib and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-inducing anticonvulsant and monitor tumor response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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