Drug interactions
Capivasertib + Fluconazole
Severity: Moderate
Capivasertib and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is metabolized mainly by CYP3A4, and fluconazole as a moderate CYP3A4 inhibitor may increase its exposure. This could worsen hyperglycemia, diarrhea, rash and other toxicities.
What this interaction means in plain words
Capivasertib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of capivasertib.
What to do
Avoid if possible or reduce the capivasertib dose per labeling during moderate CYP3A inhibitor use. Monitor blood glucose and skin and gastrointestinal toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Fluconazole?
MediHelp rates the interaction as moderate. Capivasertib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capivasertib is metabolized mainly by CYP3A4, and fluconazole as a moderate CYP3A4 inhibitor may increase its exposure. This could worsen hyperglycemia, diarrhea, rash and other toxicities.
How serious is the interaction between Capivasertib and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or reduce the capivasertib dose per labeling during moderate CYP3A inhibitor use. Monitor blood glucose and skin and gastrointestinal toxicity.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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