Drug interactions
Capivasertib + Fluvoxamine
Severity: Moderate
Capivasertib and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is metabolized by CYP3A4, and fluvoxamine can modestly inhibit this enzyme. Increased capivasertib exposure may worsen hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Capivasertib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of capivasertib.
What to do
Monitor blood glucose and tolerability. Reduce the capivasertib dose per labeling when a moderate CYP3A4 inhibitor is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Fluvoxamine?
MediHelp rates the interaction as moderate. Capivasertib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capivasertib is metabolized by CYP3A4, and fluvoxamine can modestly inhibit this enzyme. Increased capivasertib exposure may worsen hyperglycemia, diarrhea and rash.
How serious is the interaction between Capivasertib and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and tolerability. Reduce the capivasertib dose per labeling when a moderate CYP3A4 inhibitor is needed.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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