Drug interactions
Capivasertib + Ribociclib
Severity: Moderate
Capivasertib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib can increase capivasertib exposure by inhibiting its CYP3A4 metabolism. This may worsen hyperglycemia, rash and diarrhea.
What this interaction means in plain words
Capivasertib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib decreases capivasertib clearance.
What to do
Reduce the capivasertib dose per labeling for moderate CYP3A inhibitors, and monitor glucose and skin and GI toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Ribociclib?
MediHelp rates the interaction as moderate. Capivasertib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib can increase capivasertib exposure by inhibiting its CYP3A4 metabolism. This may worsen hyperglycemia, rash and diarrhea.
How serious is the interaction between Capivasertib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the capivasertib dose per labeling for moderate CYP3A inhibitors, and monitor glucose and skin and GI toxicity.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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