Drug interactions
Capivasertib + Tacrolimus
Severity: Major
Capivasertib and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib inhibits CYP3A and may raise tacrolimus concentrations, increasing nephrotoxicity, neurotoxicity and other toxicity.
What this interaction means in plain words
Capivasertib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capivasertib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated tacrolimus metabolism.
What to do
Monitor tacrolimus trough levels and renal function closely after starting or stopping capivasertib. Adjust the tacrolimus dose according to levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Capivasertib
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Capivasertib with Tacrolimus?
MediHelp rates the interaction as major. Capivasertib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capivasertib inhibits CYP3A and may raise tacrolimus concentrations, increasing nephrotoxicity, neurotoxicity and other toxicity.
How serious is the interaction between Capivasertib and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function closely after starting or stopping capivasertib. Adjust the tacrolimus dose according to levels.
What other medicines interact with Capivasertib?
MediHelp also lists interactions of Capivasertib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Capivasertib page.
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