Drug interactions
Capmatinib + Chloramphenicol
Severity: Moderate
Capmatinib and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and increase capmatinib exposure, potentially worsening adverse effects such as edema, nausea, hepatotoxicity and pneumonitis.
What this interaction means in plain words
Capmatinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capmatinib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of capmatinib.
What to do
Monitor for capmatinib toxicity including liver tests, and consider an alternative antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Capmatinib
- Amobarbital + Capmatinib Major
- Apalutamide + Capmatinib Major
- Capmatinib + Carbamazepine Major
- Capmatinib + Efavirenz Major
- Capmatinib + Enzalutamide Major
- Capmatinib + Phenytoin Major
Frequently asked questions
Can I take Capmatinib with Chloramphenicol?
MediHelp rates the interaction as moderate. Capmatinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and increase capmatinib exposure, potentially worsening adverse effects such as edema, nausea, hepatotoxicity and pneumonitis.
How serious is the interaction between Capmatinib and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for capmatinib toxicity including liver tests, and consider an alternative antibiotic if feasible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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