Drug interactions
Capmatinib + Mifepristone
Severity: Moderate
Capmatinib and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase capmatinib concentrations. Higher exposure can increase hepatotoxicity, pancreatic enzyme elevation and edema.
What this interaction means in plain words
Capmatinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capmatinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone decreases capmatinib metabolism.
What to do
Monitor liver function tests and for adverse effects, and consider a capmatinib dose reduction if toxicity develops. Prefer an alternative to mifepristone when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Capmatinib
- Amobarbital + Capmatinib Major
- Apalutamide + Capmatinib Major
- Capmatinib + Carbamazepine Major
- Capmatinib + Efavirenz Major
- Capmatinib + Enzalutamide Major
- Capmatinib + Phenytoin Major
Frequently asked questions
Can I take Capmatinib with Mifepristone?
MediHelp rates the interaction as moderate. Capmatinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase capmatinib concentrations. Higher exposure can increase hepatotoxicity, pancreatic enzyme elevation and edema.
How serious is the interaction between Capmatinib and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for adverse effects, and consider a capmatinib dose reduction if toxicity develops. Prefer an alternative to mifepristone when possible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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