Drug interactions
Captopril + Icatibant
Severity: Minor
Captopril and Icatibant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks the bradykinin B2 receptor, and part of the ACE inhibitor blood pressure effect depends on bradykinin. It could attenuate captopril's effect, although this is mostly theoretical. ACE inhibitors are also a recognized cause of bradykinin-mediated angioedema, for which icatibant is sometimes used.
What this interaction means in plain words
Captopril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Icatibant belongs to Miscellaneous.
Why it happens
Bradykinin B2 receptor antagonism may reduce the bradykinin-mediated component of ACE inhibitor effect.
What to do
Monitor blood pressure after icatibant use; no routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Icatibant
Frequently asked questions
Can I take Captopril with Icatibant?
MediHelp rates the interaction as minor. Captopril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks the bradykinin B2 receptor, and part of the ACE inhibitor blood pressure effect depends on bradykinin. It could attenuate captopril's effect, although this is mostly theoretical. ACE inhibitors are also a recognized cause of bradykinin-mediated angioedema, for which icatibant is sometimes used.
How serious is the interaction between Captopril and Icatibant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after icatibant use; no routine dose change is required.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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