Drug interactions
Fosinopril-hydrochlorothiazide + Icatibant
Severity: Moderate
Fosinopril-hydrochlorothiazide and Icatibant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks bradykinin B2 receptors, whereas ACE inhibitors raise bradykinin. This may attenuate ACE inhibitor effects, and icatibant is often used for ACE inhibitor-induced angioedema.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Icatibant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Icatibant belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism of bradykinin B2 receptor-mediated effects of ACE inhibition.
What to do
Monitor blood pressure during icatibant use. If ACE inhibitor-related angioedema is being treated, stop the ACE inhibitor and choose a different antihypertensive class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril-hydrochlorothiazide and Icatibant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Icatibant
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Icatibant?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Icatibant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Icatibant blocks bradykinin B2 receptors, whereas ACE inhibitors raise bradykinin. This may attenuate ACE inhibitor effects, and icatibant is often used for ACE inhibitor-induced angioedema.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Icatibant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during icatibant use. If ACE inhibitor-related angioedema is being treated, stop the ACE inhibitor and choose a different antihypertensive class.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
