Drug interactions
Captopril-hydrochlorothiazide + Icatibant
Severity: Minor
Captopril-hydrochlorothiazide and Icatibant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks the bradykinin B2 receptor, and ACE inhibitors raise bradykinin levels, so the two act in opposing ways. Icatibant may blunt some bradykinin-mediated effects of captopril, but its use is short-term and the clinical effect on blood pressure is probably small.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Icatibant belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at the bradykinin B2 receptor.
What to do
No routine change is needed. Note that icatibant is used for acute hereditary angioedema attacks, and ACE inhibitors are generally avoided in these patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Icatibant
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Icatibant?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks the bradykinin B2 receptor, and ACE inhibitors raise bradykinin levels, so the two act in opposing ways. Icatibant may blunt some bradykinin-mediated effects of captopril, but its use is short-term and the clinical effect on blood pressure is probably small.
How serious is the interaction between Captopril-hydrochlorothiazide and Icatibant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Note that icatibant is used for acute hereditary angioedema attacks, and ACE inhibitors are generally avoided in these patients.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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