Drug interactions
Amlodipine-benazepril + Icatibant
Severity: Minor
Amlodipine-benazepril and Icatibant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks bradykinin B2 receptors, and part of the effect of ACE inhibitors relies on bradykinin accumulation. The antihypertensive effect of benazepril could theoretically be reduced, though clinical significance is likely small.
What this interaction means in plain words
Amlodipine-benazepril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Icatibant belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism of bradykinin-mediated effects of ACE inhibition by B2 receptor blockade.
What to do
Monitor blood pressure after icatibant use in patients taking benazepril. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Icatibant
Frequently asked questions
Can I take Amlodipine-benazepril with Icatibant?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks bradykinin B2 receptors, and part of the effect of ACE inhibitors relies on bradykinin accumulation. The antihypertensive effect of benazepril could theoretically be reduced, though clinical significance is likely small.
How serious is the interaction between Amlodipine-benazepril and Icatibant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after icatibant use in patients taking benazepril. No routine dose change is needed.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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