Drug interactions
Amlodipine-perindopril + Icatibant
Severity: Minor
Amlodipine-perindopril and Icatibant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks the bradykinin B2 receptor, and part of the effect of ACE inhibitors is mediated by bradykinin. Co-use may attenuate the antihypertensive effect of perindopril, though the clinical effect is probably small. Icatibant is used short-term for acute angioedema attacks, including ACE-inhibitor induced ones.
What this interaction means in plain words
Amlodipine-perindopril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Icatibant belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism of bradykinin-mediated effects of ACE inhibition.
What to do
Monitor blood pressure around icatibant use. ACE inhibitor-induced angioedema should prompt stopping perindopril.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Icatibant
Frequently asked questions
Can I take Amlodipine-perindopril with Icatibant?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks the bradykinin B2 receptor, and part of the effect of ACE inhibitors is mediated by bradykinin. Co-use may attenuate the antihypertensive effect of perindopril, though the clinical effect is probably small. Icatibant is used short-term for acute angioedema attacks, including ACE-inhibitor induced ones.
How serious is the interaction between Amlodipine-perindopril and Icatibant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure around icatibant use. ACE inhibitor-induced angioedema should prompt stopping perindopril.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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