Drug interactions
Benazepril + Icatibant
Severity: Minor
Benazepril and Icatibant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks bradykinin B2 receptors, whereas part of the effect of ACE inhibitors relates to bradykinin accumulation. The antihypertensive effect of benazepril could therefore be somewhat reduced, though the clinical effect is probably small.
What this interaction means in plain words
Benazepril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Icatibant belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism of bradykinin-mediated effects of ACE inhibition at the B2 receptor.
What to do
Monitor blood pressure after icatibant use. Icatibant may be used for ACE inhibitor-induced angioedema, and benazepril should be stopped in that setting.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Icatibant
Frequently asked questions
Can I take Benazepril with Icatibant?
MediHelp rates the interaction as minor. Benazepril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks bradykinin B2 receptors, whereas part of the effect of ACE inhibitors relates to bradykinin accumulation. The antihypertensive effect of benazepril could therefore be somewhat reduced, though the clinical effect is probably small.
How serious is the interaction between Benazepril and Icatibant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after icatibant use. Icatibant may be used for ACE inhibitor-induced angioedema, and benazepril should be stopped in that setting.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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