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Drug interactions

Captopril + Lanthanum carbonate

Severity: Minor

Captopril and Lanthanum carbonate: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Lanthanum can bind to oral drugs in the gut and may reduce the absorption of captopril, weakening blood pressure control. The effect is predicted from cation binding and is avoidable by separating doses.

What this interaction means in plain words

Captopril and Lanthanum carbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Captopril belongs to Cardiovascular; Lanthanum carbonate belongs to Miscellaneous.

Evidence level: Low

Why it happens

Lanthanum cations bind captopril in the gastrointestinal tract, reducing absorption.

What to do

Take captopril at least 2 hours before or after lanthanum carbonate. Monitor blood pressure if dosing times cannot be separated.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Captopril with Lanthanum carbonate?

MediHelp rates the interaction as minor. Captopril and Lanthanum carbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lanthanum can bind to oral drugs in the gut and may reduce the absorption of captopril, weakening blood pressure control. The effect is predicted from cation binding and is avoidable by separating doses.

How serious is the interaction between Captopril and Lanthanum carbonate?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take captopril at least 2 hours before or after lanthanum carbonate. Monitor blood pressure if dosing times cannot be separated.

What other medicines interact with Captopril?

MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.

Full monographs, dosing and an interaction checker in the MediHelp app

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