Drug interactions
Fosinopril-hydrochlorothiazide + Lanthanum carbonate
Severity: Moderate
Fosinopril-hydrochlorothiazide and Lanthanum carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanthanum can bind to fosinopril in the gut and reduce its absorption, which may weaken blood pressure control. The effect is avoidable by separating doses.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Lanthanum carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Lanthanum carbonate belongs to Miscellaneous.
Why it happens
Chelation or binding of the ACE inhibitor by the polyvalent cation in the gastrointestinal tract reduces absorption.
What to do
Give fosinopril-hydrochlorothiazide at least 2 hours before or after lanthanum carbonate. Monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Lanthanum carbonate
- Aluminum hydroxide + Lanthanum carbonate Moderate
- Calcium carbonate + Lanthanum carbonate Moderate
- Chloroquine + Lanthanum carbonate Moderate
- Ciprofloxacin + Lanthanum carbonate Moderate
- Doxycycline + Lanthanum carbonate Moderate
- Fosinopril + Lanthanum carbonate Moderate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Lanthanum carbonate?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Lanthanum carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lanthanum can bind to fosinopril in the gut and reduce its absorption, which may weaken blood pressure control. The effect is avoidable by separating doses.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Lanthanum carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give fosinopril-hydrochlorothiazide at least 2 hours before or after lanthanum carbonate. Monitor blood pressure.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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