Drug interactions
Captopril + Lisdexamfetamine
Severity: Moderate
Captopril and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is converted to amphetamine, which raises blood pressure and heart rate and can blunt the antihypertensive effect of captopril. Blood pressure control may be lost in treated hypertensive patients.
What this interaction means in plain words
Captopril and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Sympathomimetic pressor effect of amphetamine opposes ACE inhibitor-mediated vasodilation (pharmacodynamic antagonism).
What to do
Monitor blood pressure and heart rate regularly after starting or adjusting lisdexamfetamine. Adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Captopril and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine is converted to amphetamine, which raises blood pressure and heart rate and can blunt the antihypertensive effect of captopril. Blood pressure control may be lost in treated hypertensive patients.
How serious is the interaction between Captopril and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate regularly after starting or adjusting lisdexamfetamine. Adjust the antihypertensive regimen if control is lost.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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