Drug interactions
Captopril + Rotigotine
Severity: Moderate
Captopril and Rotigotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotigotine, a dopamine agonist, can cause orthostatic hypotension and syncope. With captopril the risk of hypotension may be increased, especially at treatment initiation or dose increase.
What this interaction means in plain words
Captopril and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Rotigotine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of dopaminergic stimulation and ACE inhibition.
What to do
Monitor blood pressure including standing measurements when starting or titrating rotigotine, and counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Rotigotine
- Amisulpride + Rotigotine Major
- Metoclopramide + Rotigotine Major
- Amlodipine-benazepril + Rotigotine Moderate
- Benazepril + Rotigotine Moderate
- Captopril-hydrochlorothiazide + Rotigotine Moderate
- Clonidine + Rotigotine Moderate
Frequently asked questions
Can I take Captopril with Rotigotine?
MediHelp rates the interaction as moderate. Captopril and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rotigotine, a dopamine agonist, can cause orthostatic hypotension and syncope. With captopril the risk of hypotension may be increased, especially at treatment initiation or dose increase.
How serious is the interaction between Captopril and Rotigotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing measurements when starting or titrating rotigotine, and counsel patients to rise slowly.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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