Drug interactions
Benazepril + Rotigotine
Severity: Moderate
Benazepril and Rotigotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotigotine, a dopamine agonist, can cause orthostatic hypotension and syncope. Combined with benazepril, the risk of low blood pressure upon standing may increase.
What this interaction means in plain words
Benazepril and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Rotigotine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of dopamine agonism and ACE inhibition.
What to do
Monitor standing and sitting blood pressure during rotigotine initiation and dose titration, and counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Rotigotine
- Amisulpride + Rotigotine Major
- Metoclopramide + Rotigotine Major
- Amlodipine-benazepril + Rotigotine Moderate
- Captopril-hydrochlorothiazide + Rotigotine Moderate
- Captopril + Rotigotine Moderate
- Clonidine + Rotigotine Moderate
Frequently asked questions
Can I take Benazepril with Rotigotine?
MediHelp rates the interaction as moderate. Benazepril and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rotigotine, a dopamine agonist, can cause orthostatic hypotension and syncope. Combined with benazepril, the risk of low blood pressure upon standing may increase.
How serious is the interaction between Benazepril and Rotigotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure during rotigotine initiation and dose titration, and counsel patients to rise slowly.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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