Drug interactions
Amisulpride + Rotigotine
Severity: Major
Amisulpride and Rotigotine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride blocks dopamine receptors and opposes the effect of rotigotine, a dopamine agonist, which can worsen Parkinson's disease or restless legs symptoms. Rotigotine may also reduce the antipsychotic or antiemetic effect.
What this interaction means in plain words
Amisulpride and Rotigotine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Rotigotine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid combining; in Parkinson's disease use a non-dopamine-blocking agent such as quetiapine, clozapine or domperidone alternatives per local practice.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Rotigotine
- Metoclopramide + Rotigotine Major
- Amlodipine-benazepril + Rotigotine Moderate
- Benazepril + Rotigotine Moderate
- Captopril-hydrochlorothiazide + Rotigotine Moderate
- Captopril + Rotigotine Moderate
- Clonidine + Rotigotine Moderate
Frequently asked questions
Can I take Amisulpride with Rotigotine?
MediHelp rates the interaction as major. Amisulpride and Rotigotine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride blocks dopamine receptors and opposes the effect of rotigotine, a dopamine agonist, which can worsen Parkinson's disease or restless legs symptoms. Rotigotine may also reduce the antipsychotic or antiemetic effect.
How serious is the interaction between Amisulpride and Rotigotine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; in Parkinson's disease use a non-dopamine-blocking agent such as quetiapine, clozapine or domperidone alternatives per local practice.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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