Drug interactions
Captopril-hydrochlorothiazide + Rotigotine
Severity: Moderate
Captopril-hydrochlorothiazide and Rotigotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotigotine, a dopamine agonist, can cause orthostatic hypotension and syncope. When combined with an ACE inhibitor and a thiazide, the risk of low blood pressure may increase, especially during dose titration.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Rotigotine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from dopamine agonism and the antihypertensive agents.
What to do
Monitor supine and standing blood pressure during rotigotine initiation and titration, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Rotigotine
- Amisulpride + Rotigotine Major
- Metoclopramide + Rotigotine Major
- Amlodipine-benazepril + Rotigotine Moderate
- Benazepril + Rotigotine Moderate
- Captopril + Rotigotine Moderate
- Clonidine + Rotigotine Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Rotigotine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rotigotine, a dopamine agonist, can cause orthostatic hypotension and syncope. When combined with an ACE inhibitor and a thiazide, the risk of low blood pressure may increase, especially during dose titration.
How serious is the interaction between Captopril-hydrochlorothiazide and Rotigotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure during rotigotine initiation and titration, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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