Drug interactions
Clonidine + Rotigotine
Severity: Moderate
Clonidine and Rotigotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both clonidine and rotigotine can cause hypotension, dizziness and somnolence. Combined use may increase orthostatic hypotension, syncope and daytime sedation, particularly in older patients or at treatment initiation.
What this interaction means in plain words
Clonidine and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Rotigotine belongs to Central Nervous System.
Why it happens
Additive hypotensive and sedative pharmacodynamic effects of central alpha-2 agonism and dopamine agonism.
What to do
Monitor standing blood pressure and sedation when starting or titrating either drug. Adjust doses slowly and advise patients to rise gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Rotigotine
- Amisulpride + Rotigotine Major
- Metoclopramide + Rotigotine Major
- Amlodipine-benazepril + Rotigotine Moderate
- Benazepril + Rotigotine Moderate
- Captopril-hydrochlorothiazide + Rotigotine Moderate
- Captopril + Rotigotine Moderate
Frequently asked questions
Can I take Clonidine with Rotigotine?
MediHelp rates the interaction as moderate. Clonidine and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both clonidine and rotigotine can cause hypotension, dizziness and somnolence. Combined use may increase orthostatic hypotension, syncope and daytime sedation, particularly in older patients or at treatment initiation.
How serious is the interaction between Clonidine and Rotigotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing blood pressure and sedation when starting or titrating either drug. Adjust doses slowly and advise patients to rise gradually.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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