Drug interactions
Amlodipine-benazepril + Rotigotine
Severity: Moderate
Amlodipine-benazepril and Rotigotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotigotine, a dopamine agonist, can cause orthostatic hypotension and syncope. Together with amlodipine and benazepril, hypotension may be more frequent, particularly when starting or titrating therapy.
What this interaction means in plain words
Amlodipine-benazepril and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Rotigotine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of dopamine agonism and antihypertensive vasodilation and RAAS inhibition.
What to do
Measure standing and sitting blood pressure during rotigotine initiation and dose increases. Lower antihypertensive doses if orthostatic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Rotigotine
- Amisulpride + Rotigotine Major
- Metoclopramide + Rotigotine Major
- Benazepril + Rotigotine Moderate
- Captopril-hydrochlorothiazide + Rotigotine Moderate
- Captopril + Rotigotine Moderate
- Clonidine + Rotigotine Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Rotigotine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rotigotine, a dopamine agonist, can cause orthostatic hypotension and syncope. Together with amlodipine and benazepril, hypotension may be more frequent, particularly when starting or titrating therapy.
How serious is the interaction between Amlodipine-benazepril and Rotigotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure standing and sitting blood pressure during rotigotine initiation and dose increases. Lower antihypertensive doses if orthostatic symptoms develop.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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