Drug interactions
Captopril-hydrochlorothiazide + Carbamazepine
Severity: Moderate
Captopril-hydrochlorothiazide and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and carbamazepine can lower serum sodium, and together they may cause clinically significant hyponatremia. This can present with confusion, headache, seizures or falls, especially in older adults.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Carbamazepine belongs to Central Nervous System.
Why it happens
Additive effects on sodium handling: thiazide-induced renal sodium loss plus carbamazepine-related ADH-like water retention.
What to do
Check serum sodium at baseline and periodically, particularly after starting or changing doses. Switch the diuretic or reduce doses if sodium falls significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Carbamazepine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and carbamazepine can lower serum sodium, and together they may cause clinically significant hyponatremia. This can present with confusion, headache, seizures or falls, especially in older adults.
How serious is the interaction between Captopril-hydrochlorothiazide and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, particularly after starting or changing doses. Switch the diuretic or reduce doses if sodium falls significantly.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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