Drug interactions
Captopril-hydrochlorothiazide + Corticotropin
Severity: Moderate
Captopril-hydrochlorothiazide and Corticotropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates adrenal steroid release with mineralocorticoid activity, which promotes potassium loss and fluid retention. With hydrochlorothiazide, hypokalemia can be more pronounced and blood pressure control may worsen.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Corticotropin belongs to Endocrine.
Why it happens
Corticotropin-induced mineralocorticoid and glucocorticoid effects increase renal potassium excretion, adding to thiazide kaliuresis.
What to do
Monitor serum potassium and blood pressure during corticotropin courses. Give potassium supplementation if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Corticotropin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates adrenal steroid release with mineralocorticoid activity, which promotes potassium loss and fluid retention. With hydrochlorothiazide, hypokalemia can be more pronounced and blood pressure control may worsen.
How serious is the interaction between Captopril-hydrochlorothiazide and Corticotropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during corticotropin courses. Give potassium supplementation if needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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