Drug interactions
Captopril-hydrochlorothiazide + Dacomitinib
Severity: Minor
Captopril-hydrochlorothiazide and Dacomitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6 and could raise exposure to CYP2D6 substrates. Captopril is only partly metabolized by CYP2D6 and has a wide therapeutic margin, so a meaningful clinical effect is not expected.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Dacomitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Dacomitinib belongs to Oncology.
Why it happens
CYP2D6 inhibition by dacomitinib may modestly reduce captopril metabolism.
What to do
No routine change is needed; monitor blood pressure if the patient shows symptoms of hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Dacomitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Dacomitinib?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Dacomitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dacomitinib strongly inhibits CYP2D6 and could raise exposure to CYP2D6 substrates. Captopril is only partly metabolized by CYP2D6 and has a wide therapeutic margin, so a meaningful clinical effect is not expected.
How serious is the interaction between Captopril-hydrochlorothiazide and Dacomitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood pressure if the patient shows symptoms of hypotension.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
