Drug interactions
Captopril-hydrochlorothiazide + Desflurane
Severity: Moderate
Captopril-hydrochlorothiazide and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane cause vasodilation and myocardial depression, and patients taking ACE inhibitors and diuretics may experience pronounced hypotension during induction and maintenance of anesthesia. Volume depletion from the thiazide can make the hypotension worse.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Desflurane belongs to Central Nervous System.
Why it happens
Additive vasodilation and blunting of compensatory renin-angiotensin responses during inhalational anesthesia, with volume depletion from the diuretic.
What to do
Inform the anesthesia team about the antihypertensive regimen and consider holding the ACE inhibitor/diuretic on the morning of surgery per local protocol. Monitor blood pressure continuously and treat hypotension with fluids or vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Desflurane
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Desflurane?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane cause vasodilation and myocardial depression, and patients taking ACE inhibitors and diuretics may experience pronounced hypotension during induction and maintenance of anesthesia. Volume depletion from the thiazide can make the hypotension worse.
How serious is the interaction between Captopril-hydrochlorothiazide and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about the antihypertensive regimen and consider holding the ACE inhibitor/diuretic on the morning of surgery per local protocol. Monitor blood pressure continuously and treat hypotension with fluids or vasopressors.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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