Drug interactions
Captopril-hydrochlorothiazide + Dexmedetomidine
Severity: Moderate
Captopril-hydrochlorothiazide and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine lowers blood pressure and heart rate through central sympatholytic action, and this adds to the effect of ACE inhibitors and diuretics. Hypotension may be pronounced in volume-depleted patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive hypotension from central alpha-2 agonism and ACE inhibitor/diuretic action.
What to do
Monitor blood pressure and heart rate continuously during infusion, and correct volume status and adjust dexmedetomidine dose if hypotensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Dexmedetomidine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine lowers blood pressure and heart rate through central sympatholytic action, and this adds to the effect of ACE inhibitors and diuretics. Hypotension may be pronounced in volume-depleted patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during infusion, and correct volume status and adjust dexmedetomidine dose if hypotensive.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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