Drug interactions
Captopril-hydrochlorothiazide + Dinutuximab
Severity: Moderate
Captopril-hydrochlorothiazide and Dinutuximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dinutuximab infusions commonly cause hypotension and capillary leak, and antihypertensive drugs may add to this effect. Volume depletion from the diuretic can also increase the risk.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Dinutuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Dinutuximab belongs to Oncology.
Why it happens
Additive hypotensive effects from infusion reactions and capillary leak with vasodilating and diuretic antihypertensives.
What to do
Consider withholding the antihypertensive around dinutuximab infusions and monitor blood pressure and fluid status closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Dinutuximab
- Amlodipine-benazepril + Dinutuximab Moderate
- Benazepril + Dinutuximab Moderate
- Captopril + Dinutuximab Moderate
- Dinutuximab + Lomustine Moderate
- Dinutuximab + Oxaliplatin Moderate
- Dinutuximab + Siponimod Minor
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Dinutuximab?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Dinutuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dinutuximab infusions commonly cause hypotension and capillary leak, and antihypertensive drugs may add to this effect. Volume depletion from the diuretic can also increase the risk.
How serious is the interaction between Captopril-hydrochlorothiazide and Dinutuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding the antihypertensive around dinutuximab infusions and monitor blood pressure and fluid status closely.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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