Drug interactions
Dinutuximab + Lomustine
Severity: Moderate
Dinutuximab and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dinutuximab is used with chemotherapy, but concurrent myelosuppressive drugs can add to hematologic toxicity. Lomustine causes delayed and cumulative cytopenias that may complicate dinutuximab treatment.
What this interaction means in plain words
Dinutuximab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dinutuximab belongs to Oncology; Lomustine belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor blood counts frequently and adjust lomustine doses for cytopenias. Watch for infection during neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Dinutuximab
- Amlodipine-benazepril + Dinutuximab Moderate
- Benazepril + Dinutuximab Moderate
- Captopril-hydrochlorothiazide + Dinutuximab Moderate
- Captopril + Dinutuximab Moderate
- Dinutuximab + Oxaliplatin Moderate
- Dinutuximab + Siponimod Minor
Frequently asked questions
Can I take Dinutuximab with Lomustine?
MediHelp rates the interaction as moderate. Dinutuximab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dinutuximab is used with chemotherapy, but concurrent myelosuppressive drugs can add to hematologic toxicity. Lomustine causes delayed and cumulative cytopenias that may complicate dinutuximab treatment.
How serious is the interaction between Dinutuximab and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts frequently and adjust lomustine doses for cytopenias. Watch for infection during neutropenia.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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