Drug interactions
Captopril-hydrochlorothiazide + Eliglustat
Severity: Minor
Captopril-hydrochlorothiazide and Eliglustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6, and captopril is partly metabolized by this enzyme. However, captopril is mostly cleared renally as unchanged drug and disulfide conjugates, so a clinically meaningful change in exposure is unlikely.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Eliglustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Eliglustat belongs to Miscellaneous.
Why it happens
CYP2D6 inhibition by eliglustat could slightly reduce captopril metabolism; this pathway is minor.
What to do
No dose change is needed; monitor blood pressure as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Eliglustat?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Eliglustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits CYP2D6, and captopril is partly metabolized by this enzyme. However, captopril is mostly cleared renally as unchanged drug and disulfide conjugates, so a clinically meaningful change in exposure is unlikely.
How serious is the interaction between Captopril-hydrochlorothiazide and Eliglustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood pressure as usual.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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