Drug interactions
Captopril-hydrochlorothiazide + Ephedrine
Severity: Moderate
Captopril-hydrochlorothiazide and Ephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine can lower serum potassium modestly through beta-2 stimulation, adding to the effect of hydrochlorothiazide. Ephedrine also raises blood pressure and may blunt the antihypertensive action of the combination.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ephedrine belongs to Cardiovascular.
Why it happens
Beta-adrenergic potassium shift combined with thiazide kaliuresis, and sympathomimetic pressor opposition to antihypertensives.
What to do
Monitor blood pressure and serum potassium if ephedrine is used repeatedly or at high doses. Avoid over-the-counter ephedrine products in patients with hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Ephedrine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine can lower serum potassium modestly through beta-2 stimulation, adding to the effect of hydrochlorothiazide. Ephedrine also raises blood pressure and may blunt the antihypertensive action of the combination.
How serious is the interaction between Captopril-hydrochlorothiazide and Ephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium if ephedrine is used repeatedly or at high doses. Avoid over-the-counter ephedrine products in patients with hypertension.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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