Drug interactions
Captopril-hydrochlorothiazide + Gentamicin
Severity: Moderate
Captopril-hydrochlorothiazide and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide-induced electrolyte disturbances such as hypokalemia and hypomagnesemia may coincide with gentamicin-related renal tubular toxicity. Gentamicin also carries nephrotoxic and ototoxic risk that is increased by volume depletion from diuretics and by ACE inhibitor effects on renal perfusion.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive electrolyte wasting plus diuretic- and ACE inhibitor-related reductions in renal perfusion increase aminoglycoside nephrotoxicity.
What to do
Monitor serum creatinine, potassium and magnesium during gentamicin therapy and check gentamicin levels. Correct electrolyte and volume deficits and consider holding the diuretic during acute illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Gentamicin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide-induced electrolyte disturbances such as hypokalemia and hypomagnesemia may coincide with gentamicin-related renal tubular toxicity. Gentamicin also carries nephrotoxic and ototoxic risk that is increased by volume depletion from diuretics and by ACE inhibitor effects on renal perfusion.
How serious is the interaction between Captopril-hydrochlorothiazide and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium during gentamicin therapy and check gentamicin levels. Correct electrolyte and volume deficits and consider holding the diuretic during acute illness.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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