Drug interactions
Captopril-hydrochlorothiazide + Iloperidone
Severity: Moderate
Captopril-hydrochlorothiazide and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, which can add to the effect of captopril and hydrochlorothiazide. Dizziness, syncope and falls are most likely during dose titration.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 adrenergic blockade combined with ACE inhibition and diuresis.
What to do
Monitor orthostatic blood pressure when iloperidone is started or titrated. Reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Iloperidone?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, which can add to the effect of captopril and hydrochlorothiazide. Dizziness, syncope and falls are most likely during dose titration.
How serious is the interaction between Captopril-hydrochlorothiazide and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when iloperidone is started or titrated. Reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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