Drug interactions
Captopril-hydrochlorothiazide + Labetalol
Severity: Moderate
Captopril-hydrochlorothiazide and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol and the captopril-hydrochlorothiazide combination both lower blood pressure, and additive hypotension can occur. Effects on potassium are small and opposing, so the main concern is excessive blood pressure reduction.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through alpha/beta blockade, ACE inhibition and diuresis.
What to do
Monitor blood pressure and heart rate, especially after dose changes. Check potassium periodically and adjust doses to the blood pressure response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Labetalol?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol and the captopril-hydrochlorothiazide combination both lower blood pressure, and additive hypotension can occur. Effects on potassium are small and opposing, so the main concern is excessive blood pressure reduction.
How serious is the interaction between Captopril-hydrochlorothiazide and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially after dose changes. Check potassium periodically and adjust doses to the blood pressure response.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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