Drug interactions
Captopril-hydrochlorothiazide + Liraglutide
Severity: Minor
Captopril-hydrochlorothiazide and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can worsen glucose tolerance and offset the glucose-lowering effect of liraglutide, while captopril may modestly enhance insulin sensitivity. Net effect on glycemic control may vary, and GLP-1 related fluid loss can add to diuretic volume depletion.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Thiazides reduce insulin sensitivity and secretion, while ACE inhibitors may improve insulin sensitivity, producing opposing pharmacodynamic effects on glucose.
What to do
Monitor blood glucose when starting or changing doses of either drug. Maintain hydration and monitor renal function if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Liraglutide?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can worsen glucose tolerance and offset the glucose-lowering effect of liraglutide, while captopril may modestly enhance insulin sensitivity. Net effect on glycemic control may vary, and GLP-1 related fluid loss can add to diuretic volume depletion.
How serious is the interaction between Captopril-hydrochlorothiazide and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing doses of either drug. Maintain hydration and monitor renal function if vomiting or diarrhea occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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