Drug interactions
Captopril-hydrochlorothiazide + Lornoxicam
Severity: Moderate
Captopril-hydrochlorothiazide and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can blunt the blood pressure lowering effect of ACE inhibitors and thiazides. Together with these drugs they raise the risk of acute kidney injury, particularly in volume-depleted or elderly patients, and can contribute to hyperkalemia.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and fluid retention and reduces renal perfusion, opposing antihypertensive and diuretic effects and impairing glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium, especially at the start of therapy, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Lornoxicam?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can blunt the blood pressure lowering effect of ACE inhibitors and thiazides. Together with these drugs they raise the risk of acute kidney injury, particularly in volume-depleted or elderly patients, and can contribute to hyperkalemia.
How serious is the interaction between Captopril-hydrochlorothiazide and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, especially at the start of therapy, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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