Drug interactions
Captopril-hydrochlorothiazide + Magnesium oxide
Severity: Minor
Captopril-hydrochlorothiazide and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss, which may offset magnesium supplementation and cause hypomagnesemia with long-term use.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Thiazide-induced increase in renal magnesium excretion.
What to do
Check serum magnesium periodically in long-term thiazide users and adjust supplementation as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Magnesium oxide?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium loss, which may offset magnesium supplementation and cause hypomagnesemia with long-term use.
How serious is the interaction between Captopril-hydrochlorothiazide and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum magnesium periodically in long-term thiazide users and adjust supplementation as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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