Drug interactions
Captopril-hydrochlorothiazide + Memantine
Severity: Minor
Captopril-hydrochlorothiazide and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated renally partly by tubular secretion, and its clearance falls when urine is alkalinized. Hydrochlorothiazide could theoretically reduce its tubular clearance, and the labeling mentions possible interactions with HCTZ-containing products. Increased memantine exposure may cause dizziness, confusion or agitation.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Possible competition for renal tubular secretion of cationic drugs, reducing memantine clearance.
What to do
Monitor for increased memantine adverse effects such as dizziness or confusion, and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Memantine?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated renally partly by tubular secretion, and its clearance falls when urine is alkalinized. Hydrochlorothiazide could theoretically reduce its tubular clearance, and the labeling mentions possible interactions with HCTZ-containing products. Increased memantine exposure may cause dizziness, confusion or agitation.
How serious is the interaction between Captopril-hydrochlorothiazide and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased memantine adverse effects such as dizziness or confusion, and reduce the dose if they occur.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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