Drug interactions
Captopril-hydrochlorothiazide + Methylphenidate
Severity: Moderate
Captopril-hydrochlorothiazide and Methylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate can increase blood pressure and heart rate, which may reduce the effectiveness of antihypertensive drugs. The effect is usually modest but may be relevant in patients with hypertension.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Methylphenidate belongs to Central Nervous System.
Why it happens
Sympathomimetic pressor effect opposes the blood pressure lowering of ACE inhibitors and thiazides.
What to do
Monitor blood pressure after starting or changing methylphenidate. Adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Methylphenidate?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylphenidate can increase blood pressure and heart rate, which may reduce the effectiveness of antihypertensive drugs. The effect is usually modest but may be relevant in patients with hypertension.
How serious is the interaction between Captopril-hydrochlorothiazide and Methylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or changing methylphenidate. Adjust antihypertensive therapy if control worsens.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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