Drug interactions
Captopril-hydrochlorothiazide + Metoprolol
Severity: Minor
Captopril-hydrochlorothiazide and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with an ACE inhibitor and thiazide is common and generally beneficial, but the effects on blood pressure are additive and may cause hypotension or bradycardia. Thiazides can also worsen glucose and lipid levels, and beta-blockers may mask hypoglycemia.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects through different mechanisms.
What to do
Monitor blood pressure and heart rate when initiating or titrating. Monitor potassium and glucose periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Metoprolol?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a beta-blocker with an ACE inhibitor and thiazide is common and generally beneficial, but the effects on blood pressure are additive and may cause hypotension or bradycardia. Thiazides can also worsen glucose and lipid levels, and beta-blockers may mask hypoglycemia.
How serious is the interaction between Captopril-hydrochlorothiazide and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when initiating or titrating. Monitor potassium and glucose periodically.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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