Drug interactions
Captopril-hydrochlorothiazide + Mirabegron
Severity: Minor
Captopril-hydrochlorothiazide and Mirabegron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron moderately inhibits CYP2D6, and captopril is only partly metabolized by this pathway, so a clinically meaningful change in captopril exposure is unlikely. Mirabegron can also raise blood pressure slightly.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Mirabegron belongs to Genitourinary.
Why it happens
Weak CYP2D6 inhibition by mirabegron with minimal relevance to captopril clearance, which is largely renal.
What to do
No dose adjustment is needed. Monitor blood pressure periodically in hypertensive patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Mirabegron?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirabegron moderately inhibits CYP2D6, and captopril is only partly metabolized by this pathway, so a clinically meaningful change in captopril exposure is unlikely. Mirabegron can also raise blood pressure slightly.
How serious is the interaction between Captopril-hydrochlorothiazide and Mirabegron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor blood pressure periodically in hypertensive patients.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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