Drug interactions
Captopril-hydrochlorothiazide + Paliperidone
Severity: Moderate
Captopril-hydrochlorothiazide and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can cause orthostatic hypotension through alpha-1 blockade, and this may be additive with captopril and hydrochlorothiazide. Older or volume-depleted patients are most at risk of dizziness and falls.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Paliperidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic antagonism and ACE inhibition plus diuresis.
What to do
Monitor orthostatic blood pressure during initiation and dose increases. Lower the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Paliperidone?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can cause orthostatic hypotension through alpha-1 blockade, and this may be additive with captopril and hydrochlorothiazide. Older or volume-depleted patients are most at risk of dizziness and falls.
How serious is the interaction between Captopril-hydrochlorothiazide and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure during initiation and dose increases. Lower the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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