Drug interactions
Captopril-hydrochlorothiazide + Perphenazine
Severity: Minor
Captopril-hydrochlorothiazide and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics such as perphenazine can cause orthostatic hypotension through alpha-adrenergic blockade. When given with an ACE inhibitor and thiazide combination, the blood pressure-lowering effect may be enhanced, with a risk of dizziness and falls, especially in older patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade by perphenazine plus ACE inhibition and diuresis.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing perphenazine. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Perphenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Perphenazine?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics such as perphenazine can cause orthostatic hypotension through alpha-adrenergic blockade. When given with an ACE inhibitor and thiazide combination, the blood pressure-lowering effect may be enhanced, with a risk of dizziness and falls, especially in older patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing perphenazine. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
