Drug interactions
Captopril-hydrochlorothiazide + Potassium iodide
Severity: Moderate
Captopril-hydrochlorothiazide and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies potassium, which with ACE inhibitor therapy may raise serum potassium. Hyperkalemia is more likely with kidney disease or prolonged use.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Potassium iodide belongs to Endocrine.
Why it happens
ACE inhibition decreases aldosterone-mediated potassium excretion, compounding the potassium load.
What to do
Monitor serum potassium with repeated or prolonged potassium iodide use, particularly in renal impairment. Short single-course use usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Potassium iodide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide supplies potassium, which with ACE inhibitor therapy may raise serum potassium. Hyperkalemia is more likely with kidney disease or prolonged use.
How serious is the interaction between Captopril-hydrochlorothiazide and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium with repeated or prolonged potassium iodide use, particularly in renal impairment. Short single-course use usually needs no change.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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