Drug interactions
Captopril-hydrochlorothiazide + Saxagliptin
Severity: Moderate
Captopril-hydrochlorothiazide and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and DPP-4 inhibitors have been associated with angioedema, and combined use may increase the risk. Reactions are uncommon but can involve the airway.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Reduced breakdown of bradykinin and substance P through ACE and DPP-4 inhibition.
What to do
Counsel patients to report lip, tongue, or facial swelling immediately. Stop the offending drugs and seek emergency care if angioedema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Saxagliptin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ACE inhibitors and DPP-4 inhibitors have been associated with angioedema, and combined use may increase the risk. Reactions are uncommon but can involve the airway.
How serious is the interaction between Captopril-hydrochlorothiazide and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report lip, tongue, or facial swelling immediately. Stop the offending drugs and seek emergency care if angioedema develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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